The nasal spray vaccines have been advocated by specialists such as the future for the containment of the covid-19 pandemic, due to their easy application and reduction in the transmission of disease. Agora, a group of researchers from McMaster University, in Canada, affirms that an inalável vaccine – via aerosol particles – is the best option against respiratory tract infections.

According to the researchers, the unallocated method of vaccination delivers or contains the immunizer more deeply and offers a better defense against current and future pandemics.

Nasal spray vaccines are also considered promising for preventing respiratory infectionsSource: Shutterstock

Inhaled aerosol vaccines contour the nasal passage and release vaccine droplets into the airways, where they can induce a broad protective immune response, according to researchers, while nasal spray vaccines mostly affect only the nose and throat.

Testes with a vaccine in an aerosol

The researchers tested the study using a vaccine against tuberculosis. We will compare delivery methods by measuring droplet distribution, immune response, and immunizing potency in animals.

When the vaccine was administered directly to the lungs – via inhalation -, it stimulated stronger immune responses, providing a much higher protection against infection.

According to Matthew Miller, co-author of the study and specialist in viral diseases, infections without upper respiratory tract tend to not be serious, while infections caused by viruses such as influenza (the flu) or SARS-CoV-2 (the covid-19) tend to penetrate deep into the lungs, leaving patients really sick.

“The immune response that you will generate when you administer to the lung deeply is much stronger than when you just deposit this material in the nose and throat because of the anatomy and nature of the tissue and the immune cells that are available to respond very well. different,” Miller explained.

According to Zhou Xing, professor at the Center for Immunology Research at McMaster University, the study provides, for the first time, strong pre-clinical evidence to “support or develop vaccines with inhaled aerosol delivery for human vaccination against respiratory infections – not just covid -19, but also including tuberculosis and influenza”.

Article Frontiers in Immunology: https://doi.org/10.3389/fimmu.2022.860399.